An ingenious system for new molecules
RayDyLyo® is the capping solution suited to the economic, technological and organizational challenges of the industrial plant of the future.
The RayDyLyo® range simplifies production processes and meets the need for flexibility of manufacturers of new molecules (cell therapies, biosimilars, oncology, monoclonal antibodies), from the development phase to mass production.
![Different colors of Raydylyo Different colors of Raydylyo](/sites/default/files/styles/bootstrap_1140/public/paragraphs/image/Raydylyo-nest-Colors.jpg?itok=3RmcdYJC)
A new standard for vial capping
In response to regulatory changes, particularly in aseptic filling (Appendix 1 GMP), RayDyLyo® eliminates crimping for both liquid and lyophilized forms.
It is available in 13 and 20 mm diameters to suit different vial sizes.
Two versions are available: CTO (central tear-off) for injectable products and TTO (total tear-off, under development), for mixing and reconstitution of products.
Download the PDF file
RayDyLyo® brochure
![RayDyLyo Animation RayDyLyo Animation](/sites/default/files/styles/bootstrap_768/public/paragraphs/text_image_right/RDL%20animate%20540%20x%20540.gif?itok=pg8HdBZg)
• Suitable for ISO 8362-2 rubber stoppers, pre-validated by the customer
• Stoppers are pre-assembled automatically in the RayDyLyo® cap
- 100% camera in process control
- 100% control of stopper insertion
• Different packaging options: in standard bags, RTP type bags and nests
• Delivered sterile (RTU) or ready-to-sterilize (RTS)
• Compatible with gamma and steam sterilization
Anti-counterfeiting solution
• Patented solution
• Tamper evident features
• Colored flip cap cannot be re-installed
• Printing and labelling possible on cap body
True marketing differentiator
• 11 standard colors for the flip cap
• Ergonomic design
• Easy flip cap removal
• No risk of jagged metal edges damaging gloves
![RayDyLyo® cap RayDyLyo® cap](/sites/default/files/styles/bootstrap_768/public/paragraphs/collapse/other/RaydylyoCaps_0.jpg?itok=L5VwGQ__)
RayDyLyo is available in different packaging configurations
Different packaging options
Bulk packaging (pieces/bag) |
Ø 13 mm | Ø 20 mm |
---|---|---|
Small bag ![]() |
2 x 400 = 800 | 2 x 200 = 400 |
Big bag![]() |
2000 | 1000 |
RTP bag![]() |
3200 | 1600 |
Nested caps (pieces/nest) | Ø 13 mm | Ø 20 mm |
---|---|---|
For 2R/4R vials![]() |
100 | - |
For 6R/15R vials![]() |
- | 48 |
For 20R/30R vials![]() |
- | 25 |
For 50R vials![]() |
- | 16 |
Nests are supplied in tubs of 3
Different uses of RayDyLyo®
RayDyLyo® is suitable for use manually in clinical batch production as well as filling in isolators and serial production on filling lines.
RayDyLyo® caps are available in nests Ready-To-Use in different sizes which are compatible with commonly used nested vials. Nested caps enable gloveless filling and capping in one single step in a controlled aseptic production environment without de-nesting. Quick change over between cap sizes is easy.
![Nested aseptic capping Nested aseptic capping](/sites/default/files/styles/bootstrap_768/public/paragraphs/collapse/other/Life_Nested-Aseptic-Capping_1.jpg?itok=8E1IgNnj)
RayDyLyo and SCHOTT adaptiQ nest
![RayDyLyo and SCHOTT adaptiQ RayDyLyo and SCHOTT adaptiQ](/sites/default/files/styles/bootstrap_1140/public/paragraphs/image/RayDyLyo%26adaptiQ_4.jpg?itok=lZSd5t5V)
Aseptic Filling Solution
ARaymond, SCHOTT, and Vanrx have teamed up to design an aseptic filling solution that uses a fully automated isolator.
The ARaymondlife RayDyLyo® nested solution is available in :
- Ø20 mm for 6 to 50R vials
- Ø13 mm for 2 to 4R vials
The ARaymondlife RayDyLyo® nested solution is fully compatible with adaptiQ® nested vials designed by SCHOTT.
Nesting allows manipulation within a completely automated isolator: a nest of vials is filled and then closed with a nest of RayDyLyo® caps in one operation, without de-nesting.
Vancouver-based Vanrx Pharmasystems developed the SA25 and Microcell Aseptic Filling Workcells for use with injectable medicines.
Benefits
• No human intervention is necessary, which guarantees sterile filling.
• This RTU solution is unique: it guarantees sterile, reproducible manufacturing conditions.
• It offers greater flexibility - switching drugs between two production runs is faster - and is clearly a timesaver.
• Fast changeover between drug products
• Suitable for small to medium size batches
• No glass-to-glass contact
• Nested component products
• No need to de-nest for capping
See the video
![Infographie aseptic filling solution Infographie aseptic filling solution](/sites/default/files/styles/bootstrap_1140/public/paragraphs/image/ARlife_RayDyLyo_infographie_WebSite_1.jpg?itok=sKIyRdY6)
In 2017, the Spanish company Dara Pharmaceutical Packaging worked closely with ARaymondlife to adapt its SX-310 filling line to work with RayDyLyo® closures. Equipped with a single vibratory bowl and specific format parts for feeding and capping with RayDyLyo , the SX-310-RDL line has a reduced footprint compare to conventional lines, whilst maintaining quality standards.
Convinced by this first success,DARA and ARaymondlife decided to modify a new line (NFL/2) for processing RayDyLyo® plastic push fit caps in 2018.
The NFL line is a line dedicated to the filling and capping of ready to use (RTU) nested vials, cartridges and syringes.
Collaboration with filling line manufacturers
Modifying our equipments to work with RayDyLyo® plastic caps was quick and easy, thanks to the close collaboration with ARaymondlife” says Joan Mele, Commercial Director at Dara Pharmaceutical Packaging. "Today we are able to offer 2 lines which are operational and ready to be marketed. In particular, the NFL/2-RDL is a compact and multi format machine that makes it possible to close vials in one step on line and without de-nesting, in an aseptic area thanks to RayDyLyo®.
![ARaymond Dara collaboration ARaymond Dara collaboration](/sites/default/files/styles/bootstrap_1140/public/paragraphs/image/ARaymond_Dara_0.jpg?itok=0eIiriAC)
Machine SX-310-RDL
Compact machine for automatic infeed, filling and closing of injection vials.
Download the PDF file
ARaymondlife DARA SX-310
![Compact machine - SX-310-RDL Compact machine - SX-310-RDL](/sites/default/files/styles/bootstrap_768/public/paragraphs/text_image_right/Araymonlife_Dara_Packaging_2.jpg?itok=jNaIaYsb)
Machine NFL/2-RDL
Filling and closing machines for vials in nest and RayDyLyo® caps.
Download the PDF file
ARaymondlife DARA NLF-2
![Filling and closing machines - NFL/2-RDL Filling and closing machines - NFL/2-RDL](/sites/default/files/styles/bootstrap_768/public/paragraphs/text_image_right/Dara_Packaging.jpg?itok=J4IIioYI)